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Bruce D. Hammock

by Samantha Manning last modified Jun 26, 2015 02:49 PM

Education:

  1. B.S. in Entomology, Louisiana State University
  2. Ph.D. Entomology, University of California, Berkeley

Biography:

nsect Research

  • Exploit a fundamental understanding of insect developmental biology for the control of insect pests;
  • Develop site-directed inhibitors for enzymes involved in juvenile hormone metabolism;
  • Design chemical and biochemical agents for the disruption of insect development;
  • Use clone proteins expressed in baculovirus vectors for insect control;
  • Investigate regulation of endocrine events at the molecular level.


Mammalian Research

  • Examine the effect of hepatic enzymes on foreign compounds in our diet and the influence of these compounds on hepatic  enzymes,
  • Examine the mechanism of action of nongenotoxic carcinogens and their influence on esterases, epoxide hydrolases, and glutathione transferases;
  • Design selective inhibitors, substrates and purification systems for hepatic esterases and expoxide hydrolases;
  • Clone and hyper-express esterases and epoxide hydrolases for structural and toxicological studies.

 

Immunochemistry

  • Development of assays for serum, urinary and other biomarkers for human exposure to foreign compounds;
  • Development of immunoassays for pesticide residues in food and environmental samples;
  • Development of immunoassays for industrial wastes;
  • Development of assays for products of recombinant DNA research in agriculture;
  • Development of rapid assays for analysis of toxic metals;
  • Development of sample processing and clean up methods for immunoassays;
  • Development of immunoaffinity chromatography systems for analysis of environmental contaminants;
  • Validation of immunoassay protocols and integration with classical analytical technologies;
  • Novel methods of hapten synthesis and presentation;
  • Evaluation and development of novel immunoassay formats;
  • Encourage and provide support for the transfer of immunoassay technology to other laboratories;
  • Improve methods of antibody production and engineering.  We place heavy emphasis on PCR cloning techniques in bacterial systems followed by eukaryotic expression to yield glycosylated molecules;
  • Antibody formatting for biosensor and field portable approaches;
  • Accelerator mass spectrometry for pharmacokinetics and immunoassay.

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