The Gervay-Hague research group has established an Internationally recognized program in the area of carbohydrate chemistry directed toward the design and synthesis of chemotherapeutics targeting HIV infection and cancer. Although the disease states differ, our method of lead discovery has consistently involved understanding disease processes at a molecular level so that rational drug design can be implemented. This approach has led to studies at the interface of chemistry, biology, and virology. Our work is characterized by a total approach to drug design and synthesis that utilizes a wide variety of experimental tools available to chemists and biologists.